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Mesothelioma and Asbestos

Asbestos, a natural mineral, naturally occurs in the form of long, thin fibers. People who are exposed to Asbestos legal may develop lung diseases, such as mesothelioma.

The symptoms of these diseases may not show up for decades after exposure to asbestos legal. Different types of asbestos may cause different symptoms.

Pleural Mesothelioma

Pleural mesothelioma is a type of cancer that develops in the lung's outer liner (pleura). It is the most prevalent type of mesothelioma, making up 70 to 79% of all diagnosed cases. This condition causes chest discomfort, shortness of breath and a feeling of heaviness.

Exposure to asbestos, a class of minerals made of microscopic fibers, typically causes this type of cancer. Once inhaled, the fibers stick inside the lung and cause irritation that causes scarring and DNA mutations. Pleura is the lining of both the chest cavity and the lungs, and so irritations can also affect the heart. Mesothelioma symptoms usually don't appear until 30 to 50 years after exposure.

Chest pain and shortness breath are the most common symptoms. Patients may also suffer from chest tightness and coughing, or breathing difficulties. Patients with this type of cancer typically have a history of exposure to asbestos in the workplace. Manufacturing, construction and shipbuilding are among the most common jobs that put people at a high chance of developing pleural mesothelioma. People who were in the military are at a higher risk due to the extensive use asbestos in Navy vessels and Army bunkers.

The most popular staging system for pleural mysothelioma has been the TNM (tumor, lymph nodes and metastases) staging system. The stage that the patient is in at the time of diagnosis can help determine what treatment plan they should follow. Patients suffering from pleural mesothelioma who is in stage three or stage four will have a less favorable prognosis than those in a less advanced stage. Stage four mesothelioma often spreads to the diaphragm, liver and/or a person's heart. This makes it more difficult to treat and increases the chance of complications for patients.

Peritoneal Mesothelioma

In contrast to pleural mesothelioma which is a lung-lining cancer, peritoneal mesothelioma develops in the peritoneum -- an elongated membrane that covers the abdominal cavity and organs like the liver and intestines. Similar to pleural mesothelioma, exposure to asbestos is the cause of peritoneal mesothelioma. The disease is less prevalent than pleural mesothelioma, and around 300-500 cases being diagnosed each year.

Like pleural mesothelioma, symptoms may take years to appear. Patients usually have abdominal pain, and could also experience a mass in their abdomen. This mesothelioma type can also cause nausea, weight loss and fever. A lot of these symptoms are similar to symptoms of digestive issues, which could cause confusion in diagnosis.

Typically, doctors can identify mesothelioma by conducting an exhaustive health history and physical examination. They may also employ imaging tests such as X-rays, CT scans and PET/CT scans to identify mesothelioma. These tests can identify tumors and other cancer signs which aren't visible on X-rays.

The results of these tests allow doctors to diagnose mesothelioma and determine the stage of the disease and suggest treatment options. The stage is determined by the type of cell as well as whether the cancer has spread.

The most important mesothelioma-related risk factor is asbestos lawsuit exposure. People who have worked in asbestos-containing jobs, such as electrical or plumbing work, or in construction, manufacturing and manufacturing, are more likely to develop the disease. Even if they do not work in these areas they may be exposed to asbestos through family members or through other sources. Anyone who believes they may be at risk should talk to a doctor. A mesothelioma expert can help those with a history with asbestos to learn more about their risk.

Risk Factors

Asbestos exposure is the main mesothelioma risk factor, which accounts for as much as 80 percent of all cases. Exposure to asbestos can happen due to work, military service or by living with someone who works with asbestos or has previously done so. Asbestos particles can be inhaled by people who are exposed to asbestos. These particles can cause irritation to the linings and can cause cancerous cells to develop in the mesothelium. Mesothelioma may take between 15 and 60 years to develop after exposure to asbestos.

Other risk factors include genetics, smoking and aging. The people in their 40s or 50s are at greater risk of developing mesothelioma as compared to those who are younger or older. It takes mesothelioma between 20 and 60 years to manifest cancer symptoms after the first exposure. It is also important to know that mesothelioma can develop in those who were exposed to asbestos, but did not engage directly with it. This is referred to as indirect or secondary asbestos exposure and can be as hazardous as direct asbestos exposure.

Smoking increases a person's chances of developing mesothelioma since it damages the mesothelium and makes it more susceptible to asbestos. Mesothelioma can also be aggravated by certain illnesses such as asbestosis and pneumonia. Men are more likely to develop mesothelioma than females. This is because men are more likely to be exposed to asbestos law and endure a a longer period of exposure than women. Men are also more likely to live with someone who has had asbestos exposure and bring asbestos fibers that have escaped home on their clothes. Women tend to be less in contact with asbestos, and don't typically carry asbestos on their clothes.

Diagnosis

It is difficult to diagnose mesothelioma since its symptoms are often similar to other diseases. This can result in patients being incorrectly diagnosed.

NYU Langone doctors will perform physical examinations and document the patient's medical background, including asbestos exposure. Doctors may also request a CT scan or chest X-ray to look for abnormalities, lumps and evidence of asbestos exposure. These include pleural plaques, thickened pleura and calcium deposits.

Other diagnostic tests include a magnetic resonance scan, or MRI test, which makes use of radio waves and magnets in order to create a series detailed images of inside the body. A surgical biopsy is another method doctors use to diagnose mesothelioma. In a surgical biopsy doctors will remove a small part of tissue from the pleura or the peritoneum, to be further examined. A pathologist can look at the tissue under a microscope to see if it contains cancerous cells.

The type of mesothelial cells involved as well as the benign or malignant nature of the cells as well as the location the cancer, its type and the stage of the cancer are used to classify the disease. Some types of mesothelioma are more likely to develop metastasis or spread which is why it is crucial to have a clear diagnosis so that doctors can treat the disease before it gets out of control.

Doctors can also run tests in the lab on a tumor to find specific genes, proteins and other factors which can help them identify the characteristics of cancer and plan treatment. These results are known as staging.

Treatment

A diagnosis of mesothelioma can be frightening. But, it is crucial to remember that the disease is treatable, particularly in its initial stages. Many mesothelioma patients live for a long time with the disease without it spreading to other parts of their body.

Exposure to asbestos can trigger mesothelioma in many ways. Asbestos fibers, which are too small to detect or feel by the naked eye can become airborne and irritate the lining of the lungs (pleura). As time passes, the irritation leads to the formation of scar tissue, which eventually lead to tumors.

The pleura covers the lungs and heart and the abdomen. Mesothelium consists of cells that react when exposed to asbestos. They inflame the tissue and cause it to scar. These changes eventually result in malignant mesothelioma tumors.

Breathing problems, chest discomfort, or the accumulation of fluid on the lungs are all signs of the pleural msothelioma. In rare cases, cancer can spread into the tissues around the reproductive organs and heart.

If scans of imaging reveal an area of concern in the stomach or lungs doctors will recommend a biopsies. In the course of the procedure, doctors remove small amounts of liquid or tumor for lab tests. The results will confirm a mesothelioma diagnosis and provide the best treatment option.

There are many types of treatment for mesothelioma, such as chemotherapy and surgery. The majority of doctors employ combinations of these treatments. Patients can also benefit by taking part in a clinical trial of new mesothelioma therapies. To find out more, patients should speak with mesothelioma experts who have had experience treating the disease.

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